A general view shows a former ISIS prison in the town of Tabqa, after Syrian Democratic Forces (SDF) captured it from ISIS militants this week, Syria May 12, 2017. Picture taken May 12, 2017.

:: Three senior ISIS military leaders and planners were killed in coalition attacks in Iraq and Syria over the past two months, the coalition fighting the militants said in a statement released by the Pentagon on Friday.

Mustafa Gunes, an ISIS operative from Turkey, was killed in an air strike in Mayadin, Syria, on April 27, the statement said. Abu Asim al-Jazeri, an Islamic State planner from Algeria, was killed in Mayadin on May 11, it said.

Abu Khattab al-Rawi, an ISIS military leader, was killed in al Qaim, Iraq, on May 18, the statement said. It said all three were foreign fighters but did not identify al-Rawi’s home country.

80 relatives of ISIS militants killed

Meanwhile, a US-led coalition air strike on the eastern Syrian town of Mayadeen early Friday killed at least 80 relatives of ISIS fighters, a monitoring group told AFP.

“The toll includes 33 children. They were families seeking refuge in the town’s municipal building,” said Rami Abdel Rahman, head of the Syrian Observatory for Human Rights.

“This is the highest toll for relatives of ISIS members in Syria,” Abdel Rahman told AFP.

The latest strike came as the United Nations urged all nations bombing militant targets in Syria to better distinguish between civilian and military targets.

UN human rights chief Zeid Ra’ad Al Hussein said “all states” whose air forces are active in the anti-IS missions needed “to take much greater care to distinguish between legitimate military targets and civilians.”

The Britain-based Observatory gathered information from civilian and medical sources on the ground in ISIS-held Mayadeen, which was facing its third day of fierce bombing.

According to the Observatory, 37 civilians were killed in coalition raids on the town on Thursday night, including 13 children, and another 15 had been killed in coalition strikes on Wednesday.

The 68-member coalition began bombing ISIS targets in Iraq in the summer of 2014, and expanded their operations to Syria on September 23 of that year.

This week, the Observatory reported the highest monthly civilian death toll for the coalition’s operations in Syria.

Between April 23 and May 23 of this year, coalition strikes killed a total of 225 civilians in Syria, including dozens of children.

The US-led alliance is backing twin ground offensives against ISIS’s last main bastion cities: Raqqa in northern Syria and Mosul in neighboring Iraq.

On Thursday, a Pentagon investigation concluded that at least 105 civilians died in an anti-militant air strike on an ISIS weapons cache in Mosul in March.

Prior to the new revelation, the US military had said coalition air strikes in Iraq and Syria had “unintentionally” killed a total of 352 civilians since 2014.